Results
| PMID | 23025883 |
| Gene Name | IL10 |
| Condition | Endometriosis (ovarian) |
| Association |
Associated |
| Population size | 219 |
| Population details | 219 (112 with endometriosis, 107 without endometriosis) |
| Sex | Female |
| Associated genes | IL-10, IL-19, IL-20, IL-22 |
| Other associated phenotypes |
Ovarian endometriosis, endometrioma |
|
Fertil Steril. 2013 Jan;99(1):219-26. doi: 10.1016/j.fertnstert.2012.08.055. Epub Santulli, Pietro| Borghese, Bruno| Chouzenoux, Sandrine| Streuli, Isabelle| Borderie, Didier| de Ziegler, Dominique| Weill, Bernard| Chapron, Charles| Batteux, Frederic Laboratoire d'immunologie, EA 1833, Faculte Paris Descartes a Cochin, 75679 Paris cedex, France. santulli@inserm.fr OBJECTIVE: To determine the serum levels of interleukin (IL)-10 family ILs in women with ovarian endometriosis and investigate the correlation of these levels with disease activity. DESIGN: A case-control laboratory study. SETTING: Tertiary-care university hospital. PATIENT(S): Two hundred nineteen women, with (n = 112) and without (n = 107) endometriosis. INTERVENTION(S): Complete surgical excision with pathological analysis. MAIN OUTCOME MEASURE(S): Blood samples were obtained during surgical procedures. IL-10, -19, -20, and -22 were assayed by ELISA in sera, and the concentrations correlated with the extent and the severity of the disease. RESULT(S): IL-19 was detectable in 18.3% and IL-22 in 47.9% of sera samples from all 219 women studied. Serum IL-19 was lower in women with endometriosis (median, 292.7 pg/mL; range, 32.2-1,339.3) than in endometriosis-free women (median, 1,035.8 pg/mL; range, 32.2-2,000.0). In addition, serum IL-22 levels were decreased in women affected by endometriosis (median, 352.0 pg/mL; range, 31.2-1,392.2) as compared with endometriosis-free women (median, 709.2 pg/mL; range, 73.3-2,012.0). We found significant correlations between serum IL-22 concentrations and intensity of deep dyspareunia (r = -0.303) and noncyclic chronic pelvic pain (r = -0.212). IL-19 was correlated with the intensity of deep dyspareunia (r = -0.749). CONCLUSION(S): Serum IL-19 and IL-22 are decreased in women with ovarian endometrioma. IL-10 family ILs may be involved in the pathogenesis of endometriosis. Mesh Terms: Adult| Case-Control Studies| Endometriosis/*blood/physiopathology| Female| Humans| Interleukin-10/blood| Interleukins/*blood| Ovarian Diseases/*blood/physiopathology| Retrospective Studies| Severity of Illness Index|DA 2013/04/06 06:00 |
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